Pamplico is a town in southeastern Florence County, South Carolina, United States. The population was 1,226 at the 2010 census. It is part of the Florence Metropolitan Statistical Area. Pamplico is located in eastern Florence County at 33°59′46″N 79°34′4″W / 33.99611°N 79.56778°W. It is located 3 miles west of the Pee Dee River and 19 miles southeast of …Pamplico is a town in southeastern Florence County, South Carolina, United States. The population was 1,226 at the 2010 census. It is part of the Florence Metropolitan Statistical Area. Pamplico is located in eastern Florence County at 33°59′46″N 79°34′4″W / 33.99611°N 79.56778°W. It is located 3 miles west of the Pee Dee River and 19 miles southeast of Florence, the county seat. South Carolina Highway 51, a secondary thoroughfare for traffic to Myrtle Beach, passes through the town center. Myrtle Beach is 51 miles to the southeast.
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