Pregnant opiate-dependent women experience a 6-fold ... [13] It may be that methadone metabolism may be altered in late pregnancy, possibly due to the effect of progestins on hepatic drug metabolism.

The nebulization of opioids delivers medication directly into the airways and hence into the pulmonary circulation. Hepatic first-pass metabolism is avoided, and this route has been advocated as ...

Opioid analgesic risk evaluation and mitigation strategy (REMS); Ultra-rapid metabolism of codeine and other risk factors for life-threatening respiratory depression in children; Interactions with ...

Alarmingly, opioids contributed to 75% of these fatalities ... By targeting overlapping pathways in addiction and metabolism, these drugs may complement existing pharmacological treatments.

One of the world’s largest studies of Ozempic, Mounjaro and other blockbuster diabetes and obesity drugs highlighted their ...