Brain metabolism and hypoxia are critical areas of study in understanding the effects of substance use, particularly with opioids like fentanyl and heroin. These substances can significantly alter ...

3 In 2016, the Massachusetts Department of Industrial Accidents (DIA), which administers the Massachusetts workers’ compensation program, initiated the Opioid Alternative Treatment Pathway (OATP) (ppt ...

Methadone, a synthetic opioid, helps to reduce withdrawal symptoms ... explored various genetic factors that influence methadone metabolism and treatment response. One key area of research has ...

Pregnant opiate-dependent women experience a 6-fold ... [13] It may be that methadone metabolism may be altered in late pregnancy, possibly due to the effect of progestins on hepatic drug metabolism.

The nebulization of opioids delivers medication directly into the airways and hence into the pulmonary circulation. Hepatic first-pass metabolism is avoided, and this route has been advocated as ...

Opioid analgesic risk evaluation and mitigation strategy (REMS); Ultra-rapid metabolism of codeine and other risk factors for life-threatening respiratory depression in children; Interactions with ...

Researchers from Tokyo University of Science uncover cellular and molecular mechanisms underlying the antidepressant-like effects of the delta opioid receptor agonists, paving the way for its ...

Alarmingly, opioids contributed to 75% of these fatalities ... By targeting overlapping pathways in addiction and metabolism, these drugs may complement existing pharmacological treatments.