Figure 2: Human APC and CTNNB1 mutations are ... Many cases of FEVR are linked to loss-of-funtion mutations in the Wnt receptor FZ4 (Frizzled 4). Loss-of-function mutations in WNT3 cause tetra ...
Wnt binds to the Fz receptor and LRP5/6 co-receptor. This activates Dvl to cause the dissociation of Axin from the destruction complex, causing β-catenin to be stabilized and enter the nucleus.
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