Heroes, Warriors, and Martyrs—may be biologically imprinted in our DNA. Science, psychology, and epigenetics reveal the roots ...

To address this, we present Archetypal Analysis network (AAnet), a neural network that learns key archetypal cell states within a phenotypic continuum of cell states in single-cell data.

scAAnet is an autoencoder-based neural network which can perform nonlinear archetypal analysis on single-cell RNA-seq data. The underlying assumption is that the expression profile of each single cell ...