In other patients, it is associated with nondiabetic insulin resistance ... The classical mechanism of PKC activation is through ligand binding to G-protein-coupled receptors, which for example ...
Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...
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Insulin degradation uncovered as a new driver of resistanceNew study identifies insulin ‘chain-splitting’ during bloodstream transit as a game-changer in understanding and treating diabetes and insulin resistance. Study: Chain splitting of insulin: an ...
LPS receptor-deleted mice (i.e., CD14 mutants) are hypersensitive to insulin, and the occurrence ... of plasma LPS are a sufficient molecular mechanism for triggering the high-fat diet-induced ...
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