生物通15d
PPAR在结直肠癌中的调控作用
随着研究的不断深入，有研究揭示，作为转录因子的过氧化物酶体增殖物激活受体（PPARs）与结直肠癌有着千丝万缕的联系。深入了解 PPARs 相关通路，或许能为以 PPARs 为潜在靶点开发结直肠癌 ...
Nature16d
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear receptor that has a critical role in adipogenesis, glucose metabolism and placental function 1,2,3.
BMJ18d
Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonists may become effective therapeutic targets. Objective To ...
The Lancet20d
Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia
dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...
BMJ15d
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
5 Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA 6 Division of ...