Numerous working models have been proposed to integrate the complexities of environmental, biochemical, genetic and neuropathological evidence, but a more simplistic model of PD pathogenesis ...
Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state
substantia nigra pars compacta; SNr, substantia nigra pars reticulata; STN, subthalamic nucleus; VA, ventral anterior nucleus of thalamus; VL, ventrolateral nucleus of thalamus. The general anatomical ...
These symptoms are due to the loss principally of dopaminergic neurons of the substantia nigra (SN) par compacta and the GABAergic neurons of the striatum in PD and HD, respectively. Although these ...
Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions between environmental and genetic factors. Metabolomics can shed light on alterations in metabolic pathways in many ...
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