(5) For Figure 5B, it would be interesting if the authors could ... but the authors show that a chimeric FZD5CRD-FZD4 receptor can confer Wnt-dependent endocytosis to an otherwise endocytosis ...

FIGURE 1. Canonical BMP signaling pathway. BMP ligands (yellow and green) bind to type II serine-threonine kinase receptors, which recruit and phosphorylate ... approaches have unraveled that maternal ...

The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...

To determine whether increased androgen receptor protein concentration has a causal role in the hormone sensitive-to-hormone refractory transition, we introduced epitope-tagged wild-type AR cDNA ...

1995; Yasuda et al. 1988). Instead, both OPC-14597 and OPC-4392 exhibit clear antagonist actions at postsynaptic receptors, as evidenced by inhibition of apomorphine-induced stereotypy and ...

Androgen receptor (AR) is frequently expressed in diverse BC subtypes ... Moreover, recent studies have shown that the aberrant activation of the EMT and Wnt/β-catenin pathway also contributes to ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...

Centre for Endocrinology, William Harvey Research Institute, Bart’s and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K. School ...

IgG1 and IgG2a were only significantly reduced following treatment with dexamethasone compared with the positive control group (figure 4D). Previous studies have reported an association between NP and ...

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States Department of Molecular Biology and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital ...