The Lancet2d
First phase 3 trial of GLP-1 receptor agonist for neurodegeneration
The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...
eLife18d
Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
(5) For Figure 5B, it would be interesting if the authors could ... but the authors show that a chimeric FZD5CRD-FZD4 receptor can confer Wnt-dependent endocytosis to an otherwise endocytosis ...
Frontiers23d
The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function
1 Immunology Graduate Program, Baylor College of Medicine, Houston, TX, United States 2 Department of Pathology, University of Utah, Salt Lake City, UT, United States Introduction: Chimeric antigen ...
Cancer Research25d
Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma
1Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China. 2Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. 3Key ...
Frontiers26d
Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases
To investigate the cell-cell interactions between different cell types in the normal scar samples and keloid samples, cellular spatial organization mapper (CSOmap) software (v1.0) was used to identify ...