UroToday10d
Comparing Autologous and Mesh Slings for Stress Incontinence Efficacy and Safety - Ariana Smith
Comparing Autologous and Mesh Slings for Stress Incontinence Efficacy and Safety - Ariana Smith ...
UroToday3mon
Prostate Cancer
Rates of PSMA PET Staging and Positivity in Newly Diagnosed Prostate Cancer in a National Health Care System. January 7, 2025 Prostate Cancer Patient With Lymph-node Metastasis Treated Only With ...
UroToday3d
Circulating immune biomarkers correlating with response in patients with metastatic renal cell carcinoma on immunotherapy.
As multiple front-line immune checkpoint inhibitor (ICI)-based combinations are approved for metastatic renal cell carcinoma, biomarkers predicting for ICI responses are needed past clinical ...
UroToday4d
Networks of pre-diagnostic circulating RNA in testicular germ cell tumour.
Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors, affecting young men. We have previously identified several hundred differentially abundant circulating RNAs in pre ...
UroToday4d
The Clinical Role of Hypoxia Inducible Factor (HIF) Inhibition in Renal Cancer: A Focus on Belzutifan.
Systemic therapy for metastatic Renal Cell Carcinoma (mRCC) has dramatical-ly improved in the last years because of the use of immunotherapy with checkpoint inhibi-tor combinations with or without ...
UroToday4d
Paediatric renal tumours: an update on challenges and recent developments.
Paediatric renal tumours include a broad range of neoplasms which largely differ, but also overlap to a smaller extent, with adult kidney cancer. These include the embryonal tumour nephroblastoma, ...
UroToday4d
The interaction of structured data using openEHR and large Language models for clinical decision support in prostate cancer.
Multidisciplinary teams (MDTs) are essential for cancer care but are resource-intensive. Decision-making processes within MDTs, while critical, contribute to increased healthcare costs due to the need ...
UroToday4d
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal.
Using joint genomic-transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor ...
UroToday5d
Diagnostic Accuracy of VI-RADS for Determining Muscle Invasion - Expert Commentary
Treatment selection in bladder cancer (BC) depends on the accurate determination of muscle invasion in transurethral resection of bladder tumor (TURBT). However, there are various limitations to TURBT ...
UroToday4d
Cost-Effectiveness of PARP Inhibitors for Patients with BRCA1/2-Positive Metastatic Castration-Resistant Prostate Cancer-The Canadian Perspective.
Through phase III clinical trials, PARP inhibitors have demonstrated outcome improvements in mCRPC patients with alterations in BRCA1/2 genes who have progressed on a second-generation androgen ...
UroToday5d
The Emerging Predictive and Prognostic Role of Aggressive-Variant-Associated Tumor Suppressor Genes Across Prostate Cancer Stages.
Aggressive variant prostate cancer (AVPC) is characterized by a molecular signature involving combined defects in TP53, RB1, and/or PTEN (AVPC-TSGs), identifiable through immunohistochemistry or ...
UroToday4d
Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience.
Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with a poor prognosis and an unmet need for biomarkers. We performed a retrospective evaluation of real-world ...