New research suggests that δ-receptor agonists regulate intestinal motility and relieve abdominal pain in a mouse model of irritable bowel syndrome, potentially offering a novel CNS-targeted ...

One of the reasons for this dramatic, full-body response is that naloxone binds to opioid receptors all over the body, triggering involvement from organs like the skin and intestines, and not just ...

University of Mississippi researchers have discovered how a compound found in cannabis might be used to mitigate the negative effects of THC, a psychoactive compound in the plant. This ...

A118G (43AA, 19AG, 18GG) 80 Taiwan females following abdominal hysterectomy GG had significantly higher postoperative day 1 morphine requirements [104] A118G Caucasians: 66 = AA, 29AG; Africans: 1 ...

Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

Endo's slide into bankruptcy follows in the footsteps of Purdue Pharma – which filed in 2019 but is still negotiating opioid settlement and corporate restructuring terms – as well as ...

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

Preliminary data from the team has already shown that in mouse models inhibiting the M5-receptor significantly reduces the addiction to prescribed opioids, whilst still maintaining pain relief ...