Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites ...

Objective Hepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this ...

Division of Hepatology and Metabolism, Department of Internal Medicine, Saga Medical School, Saga, Japan Dr I Ozaki, Division of Hepatology and Metabolism, Department of Internal Medicine, Saga ...

1 Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong 2 Department of Gastroenterology, Ruijing Hospital North, School of Medicine, ...

1 Dalhousie Inflammation Group and Department of Pediatrics, and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada 2 Dalhousie Inflammation Group and ...

Objective To appraise the evidence that pathophysiological mechanisms and individualised treatment directed at those mechanisms provide an alternative approach to the treatment of patients with ...

2 Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China Background Tumourigenesis in right-sided and left-sided colons demonstrated ...

Background Functional dyspepsia (FD) is a heterogeneous complex of symptoms presenting with effects in the upper gastrointestinal tract. With negative diagnostic workup, the diagnosis is based solely ...

Correspondence to Dr Barham K Abu Dayyeh, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R), Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, ...

1 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Greenebaum Cancer Center, Baltimore, Maryland, USA 2 Division of Gastroenterology and Hepatology, ...

Mrs K Cauch-Dudek, Toronto Hospital, Western Division, 399 Bathurst St, West Wing 4–833, Toronto, Ontario M5T 2S8, Canada. Background—Fatigue is a frequent and debilitating symptom in patients with ...

Objective To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United ...