The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove of genes that influence cognition, and these could be therapeutic targets, ...

Stop the Spread. Injecting saline into mouse kidneys did not affect the left or right substantia nigra (top). Injecting fibrils of α-synuclein ablated about half of the dopaminergic neurons (middle ...

Missense mutations that derail SORL1 trafficking cause AD. Other variants shift AD risk in East Asians and Europeans. SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in ...

The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

I have no competing interest.

Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

EBP1 is low in Alzheimer’s disease brains, hinting at human relevance. “Our study suggests that … preservation of functional EBP1 could be a therapeutic strategy for AD,” the authors noted. The ...

Michael Breakspear, M.B. B.S., B.Sc., B.A., FRANZCP, Ph.D. Newcastle, Australia ...

Could inhaling xenon gas help fight Alzheimer’s disease? In the January 15 Science Translational Medicine, scientists led by Oleg Butovsky at Brigham and Women’s Hospital, Boston, and David Holtzman ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...